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Showing posts with the label BBV152

Retinal occlusion after vaccination with vector, RNA, subunit and inactivated COVID-19 vaccines

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A 13-year-old boy presented to the hospital with a complaint of painless diminution of vision in the left eye for 2 weeks. It started 15 days after taking the first dose of Corbevax COVID-19 vaccine. Corbevax, also known as BACOV2A, is a  recombinant protein subunit vaccine  approved for emergency use in India  o n 28 December 2021. Fundus fluorescein angiography of the left eye showed a delay in venous filling in the early phase of angiogram and blocked fluorescence corresponding to the areas of hemorrhages revealed by fundus examination.  The patient was administered three doses of pulse corticosteroids followed by a tapering dose of oral corticosteroids. A t 6 weeks follow-up, fundus revealed complete resolution of the retinal hemorrhages and disk edema. A 44-year-old otherwise healthy male   presented with sudden painless vision loss in his left eye 10 days after receiving i nactivated vaccine Covaxin/BBV152 . Fundus examination revealed arterial attenuati...

Fatal COVID-19 breakthrough due to omicron subvariant

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A centenarian who had survived a hundred years of ups and downs of life died from breakthrough COVID-18 on Saturday, June 25th , 2022 .  He was suffering from multiple ailments like renal issues,  blood pressure, diabetes and was admitted to a private hospital where he tested positive for the virus. He was on liquid diet as was not able to eat properly. He died 7 days later.  Neither of his family members tested positive for SARS-Cov-2 The individual was vaccinated with two doses of Covaxin  -  also known as BBV152, a whole inactivated virus-based COVID-19 vaccine developed by Bharat Biotech in collaboration with the Indian Council of Medical Research - National Institute of Virology.  Currently India is experiencing the fourth wave of COVID-19 dominated by BA.2.75 (dubbed " Centaurus ", BA.5 and BA.4 A  very early analysis  of data from India by Raj Rajnarayanan indicates that BA.2.75 may have a growth advantage over BA.5. It is unclear, as yet...

Pericardial effusion as a complication of vaccination against COVID-19

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We present two cases following inactivated virus and mRNA vaccines and discuss additional cases of fetal pericardial effusion after maternal COVID-19 vaccination.  A 34-year-old man without any significant past medical history experienced chills and fever 48 hours after inoculation of the Sinopharm vaccine. He had taken Acetaminophen to control the fever; however, on the third day post-vaccination, he developed an atypical pleuritic chest pain for which he was brought to our center. A pan-CT scan with intravenous contrast was performed and showed no findings suggestive of malignant lesions nor any lesions in favor of neoplastic processes. Peritracheal lymph nodes were found with less than 10 mm diameter showing benign reactive lymph nodes. The patient was on nonsteroidal anti-inflammatory drugs and Colchicine with suspicion for pericarditis but no improvement was seen in his condition evaluated by serial echocardiograms. Therefore, a pericardial window was inserted for him and the...