Medical Case Reports

New case report describes a 56-year-old woman who developed debilitating symptoms, including intense foot pain, discoloration, and swelling, following COVID-19 vaccination with the Pfizer-BioNTech mRNA vaccine. The patient experienced acrocyanosis, constant pain in the soles of her feet, and a throbbing sensation. Symptoms worsened after each COVID-19 vaccine dose, leading to dependency on a wheelchair. Dermatological manifestations included redness, discoloration, and swelling. Initial evaluations suggested erythromelalgia, but subsequent investigations involved multiple medical specialties, including dermatology, vascular surgery, rheumatology, neurology, and orthopedics. Various diagnostic tests, including blood tests, genetic testing, imaging, and biopsies, yielded inconclusive results. Based on the Budapest Criteria for CRPS, the patient fulfilled the criteria, exhibiting allodynia, hyperalgesia, skin color changes, edema, continuing pain, and the absence of a more obvious explan

Leukopenia, a condition characterized by a decrease in white blood cell count, is a medical phenomenon that warrants attention, especially when linked to the initiation of medications. In a newly published case report, a 20-year-old bipolar woman experienced leukopenia following the administration of lamotrigine, next day after COVID-19 vaccine booster, shedding light on potential risks and interactions. Lamotrigine is known for its efficacy in treating bipolar disorder, but like any medication, it comes with potential side effects. Adverse effects are more likely when lamotrigine is used alongside other antiepileptic drugs, during rapid dose titration, or in combination with multiple medications. Monitoring its concentration becomes crucial in such cases, as highlighted in this report. The patient in question received lamotrigine the day after her third mRNA vaccination for COVID-19, presenting with predisposing factors such as concomitant use of antiepileptic drugs. Surprisingly, leu

New paper discusses a case report of a 65-year-old woman who experienced neurological complications following the administration of a third dose of the Moderna COVID-19 vaccine. The patient, previously in good health, presented with symptoms that included numbness in the mouth, feet, legs, interscapular space, and hands, along with muscle pain in the lower limbs and interscapular pain. The clinical evaluation by a neurologist revealed distal and asymmetric sensory axonal polyneuropathy predominantly affecting the right lower limb. Electromyography (EMG) and electroneurography (ENG) tests were conducted to assess the nerve function. The study showed an exclusively sensory polyneuropathy of the axonal type with a distal and asymmetric distribution, predominantly in the right lower limb. There were also findings suggestive of neuropathy due to entrapment of the distal segment of the right median nerve in its course through the wrist.  The patient's blood work showed elevated transamin

Patients with adrenal insufficiency who are on glucocorticoid replacement therapy face unique challenges when it comes to vaccination. In most cases, conventional vaccines like those for the influenza virus don't necessitate an increase in glucocorticoid dose. However, with the advent of COVID-19 mRNA vaccines, there have been reported cases of adrenal crisis in patients with secondary adrenal insufficiency. A new paper explores three cases that shed light on this issue.  Case 1: Idiopathic Isolated ACTH Deficiency A 78-year-old man with idiopathic isolated ACTH deficiency received the second dose of the BNT162b2 mRNA vaccine. He decided not to take hydrocortisone (HC) on the day of vaccination. The following day, he experienced fatigue, nausea, vomiting, and appetite loss. He did not receive HC and ended up in the emergency department two days later, with severe general fatigue, nausea, vomiting, hyponatremia, and relative hypotension. His symptoms resolved a day after administrat

On October 13, 2023, the golfing world lost an eleven-time PGA Tour winner Andy Bean. He was 70. His demise came six weeks after undergoing a double-lung transplant to address severe lung damage caused by a battle with COVID-19.  Born on March 13, 1953, Thomas Andrew Bean spent his formative years on the picturesque Jekyll Island, Georgia, before his family relocated to Lakeland, Florida. The move was inspired by his father Tommy's passion for golf, which led to the development of a golf course in Lakeland. Andy Bean's connection to the sport grew stronger as he went on to attend the University of Florida, where he played alongside teammates Gary Koch, Woody Blackburn, and Phil Hancock, helping the Gators secure the 1973 NCAA Championship.  Bean turned professional in 1975, embarking on a journey that would establish him as one of the PGA Tour's most consistent performers. Standing at an impressive 6-foot-4, Bean even gained notoriety for an incident where he "wrestled

In late July 2021, a 67-year-old woman vaccinated with Sinopharm COVID-19 vaccine (inactivated virus) presented a unique and challenging medical case that underscores potential neurological consequences of both infection and vaccination.  The patient's journey began with the onset of common COVID-19 symptoms: fever, myalgia, mild dyspnea, headache, and a non-productive cough. She had no pre-existing medical conditions. Upon her initial evaluation, her vital signs were within a relatively stable range, with the exception of a slightly decreased oxygen saturation (SpO2) of 91%. Physical examination did not reveal any significant findings. Her positive SARS-CoV-2 polymerase chain reaction test prompted further investigation, given the mild dyspnea and decreased SpO2. A chest computed tomography scan revealed peripheral consolidation and ground glass opacities, typical of COVID-19 pneumonia. Treatment commenced with Dexamethasone and Remdesivir alongside supplemental oxygen. Over the