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Showing posts from May, 2022

Long COVID symptoms don't resolve due to subsequent vaccinations

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A new study from Mount Sinai  followed 453 COVID-19 patients with  post-acute sequelae of COVID ( PASC). 324 (72%) of them were vaccinated in the following 6 months. Unadjusted analyses did not show significant changes in anosmia, respiratory symptoms, depression, anxiety, PTSD, or quality of life ( p  > 0.05 for all comparisons) among vaccinated vs. unvaccinated patients. Similar results were found in propensity-adjusted comparisons and in secondary analyses based on the number of vaccine doses received. An older not-yet-peer-reviewed study  found that those who were vaccinated before catching COVID had only a 13% lower risk than unvaccinated patients of having PASC symptoms (mostly lung-related) six months later .  According to the lead author of this study, reliance on vaccination as a sole mitigation strategy is wholly inadequate. Here are a few case reports about Long COVID in the vaccinated individuals.   CASE REPORTS A previously healthy 47-year-old woman was evaluated for

Fatal Breakthrough COVID-19 in a Heart Transplant Recipient

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A 71-year-old male presented with two days’ shortness of breath, myalgias, and chills in March 2021.  His temperature was 99.0 °F and heart rate was 108 beats/minute. The patient had received two doses of the COVID-19 vaccine four weeks apart, with the second dose 16 days prior to admission. Laboratory exams were significant for lymphopenia and acute kidney injury (AKI).  His brain natriuretic peptide (BNP) level was found to be elevated (an indicator of heart failure). A chest X-ray showed cardiomegaly with pulmonary vascular engorgement and an electrocardiogram showed an atrial-sensed, ventricular-paced rhythm. 5 years prior the patient received an orthotopic heart transplant. The biopsy ruled out rejection. He also had a history of obesity, hypertension, unprovoked deep vein thrombosis, and dual chamber pacemaker. The patient was started on dexamethasone and remdesevir and his tacrolimus dose was adjusted to maintain therapeutic serum levels. The patient’s AKI improved with fluid re

Pericardial effusion as a complication of vaccination against COVID-19

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We present two cases following inactivated virus and mRNA vaccines and discuss additional cases of fetal pericardial effusion after maternal COVID-19 vaccination.  A 34-year-old man without any significant past medical history experienced chills and fever 48 hours after inoculation of the Sinopharm vaccine. He had taken Acetaminophen to control the fever; however, on the third day post-vaccination, he developed an atypical pleuritic chest pain for which he was brought to our center. A pan-CT scan with intravenous contrast was performed and showed no findings suggestive of malignant lesions nor any lesions in favor of neoplastic processes. Peritracheal lymph nodes were found with less than 10 mm diameter showing benign reactive lymph nodes. The patient was on nonsteroidal anti-inflammatory drugs and Colchicine with suspicion for pericarditis but no improvement was seen in his condition evaluated by serial echocardiograms. Therefore, a pericardial window was inserted for him and the per

Urological Adverse Effects of COVID-19 Vaccination

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Urological Adverse Events of vaccination (AEs) were reported in several studies mostly focusing on  storage lower urinary tract symptoms (LUTS), including urinary urgency and urinary frequency. Recent analysis investigated LUTS before and after the first dose of COVID-19 vaccine and the association between pre-vaccinated overactive bladder (OAB) and the worsening of storage LUTS following COVID-19 vaccination. This cross-sectional study in a third-level hospital in Taiwan used the validated pre- and post-vaccinated Overactive Bladder Symptom Score (OABSS). Diagnosis of OAB was made using pre-vaccinated OABSS. The deterioration of storage LUTS was assessed as the increased score of OABSS following vaccination. Of 889 subjects, up to 13.4% experienced worsened storage LUTS after vaccination. OAB was significantly associated with an increased risk of worsening urinary urgency (p = 0.030), frequency (p = 0.027), and seeking medical assistance due to urinary adverse events (p < 0.001) a

Fatal autoimmune acquired factor XIII/13 deficiency after COVID‐19 vaccination

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A 78‐year‐old woman with no personal or family history of abnormal bleeding noticed a bruise on her thigh 2 weeks after her second COVID‐19 mRNA vaccination (Pfizer‐BioNTech). Her skin bruise persisted and on day 38, a new bruise appeared on her left hand. On day 50, she visited a hospital because of pain and swelling in the left hand.  Computed tomography (CT) scans showed intra‐articular bleeding in her left shoulder and asymptomatic central nervous system (CNS) bleeding. Blood tests revealed normocytic anemia. While factor XIII/13 (F13) antigen level was slightly reduced, and its activity was below the detection limit. The patient died of CNS bleeding despite treatment.  READ MORE REFERENCE Shimoyama S, Kanisawa Y, Ono K, Souri M, Ichinose A. First and fatal case of autoimmune acquired factor XIII/13 deficiency after COVID‐19/SARS‐CoV‐2 vaccination. American journal of hematology. 2022 Feb;97(2):243.

Triple-vaccinated 70-year-old dies from breakthrough COVID-19 during the Omicron wave

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Previously healthy and fit (bicycling, scuba diving) 70-year-old man became ill with COVID-19 in December 2021. He was fully vaccinated and boosted. When his breathing became labored, he was admitted to the emergency room at George Washington University Hospital. His treatment included a monoclonal antibody.  But despite his robust good health and fitness level, he never left the hospital. He died after spending a month in the hospital. One of his last acts of generosity occurred as he was dying. Some of his blood was drawn for COVID-19 research that will hopefully save lives.  REFERENCES https://www.washingtonpost.com/health/2022/04/29/covid-deaths-unvaccinated-boosters/ https://dc.eater.com/2022/1/18/22881891/scott-bennett-amsterdam-falafelshop-adams-morgan-death https://www.nbcwashington.com/news/coronavirus/founder-of-amsterdam-falafel-shop-dies-of-covid-after-month-in-hospital/2937497/ https://www.gofundme.com/f/to-be-continued-the-scott-bennett-memorial-fund

Long Breakthrough COVID: 4 case reports

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A previously healthy 47 year-old woman was evaluated at our post-COVID clinic for 7 months of PASC symptoms. She developed acute COVID-19 infection in the summer of 2021 and had received two doses of the BNT162b2 (Pfizer-BioNTech) vaccine 6 months prior to the onset of her infection. Her acute symptoms included cough, sore throat, altered smell and taste, headache, fever, chills, body aches, chest pressure, and fatigue, which were managed with home care. COVID-19 infection was confirmed by PCR test. Most acute symptoms resolved after 48 hours, but over the next several months she continued to suffer severe fatigue, cognitive difficulties, post-exertional malaise, insomnia, tachycardia, chest pressure, and body aches resulting in significant functional debilitation and a leave of absence from work. She also experienced headaches and hair loss, both of which self-resolved. 6-months post-infection, the patient was potentially exposed to COVID-19 again and developed new symptoms of headac

Fatal Guillain-Barré syndrome after AstraZeneca COVID-19-vaccination

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A  fit and healthy 77-year-old woman  got her first dose of the AstraZeneca vaccine in July 2021. Within weeks she went from doing her own shopping and loading firewood to being paralyzed, relying on her children and hospital staff to hand-feed her. She also experienced delusions and hallucinations.  She died in hospital on September 5 last year, leaving four children, six grandchildren and three cats. The cause of death listed on her death certificate is "Guillain-Barre syndrome in the setting of recent AstraZeneca vaccination". The  Therapeutic Goods Administration  (TGA) of Australia has identified 11 deaths linked to the first dose of AstraZeneca – "eight were thrombosis with thrombocytopenia syndrome (TTS) cases, two were linked to Guillain-Barre syndrome (GBS), and one was a case of immune thrombocytopenia (ITP)". REFERENCES https://www.abc.net.au/news/2022-05-17/covid-vaccines-booster-astrazeneca-australian-deaths/101055494 https://www.msn.com/en-au/health/me