Showing posts from August, 2023

Treatment of COVID-19 Vaccine-triggered Migraine

A 55-year-old woman with a long history of chronic migraines saw her symptoms worsen after getting a COVID-19 mRNA vaccine. Normally, her migraines were manageable with topiramate and sertraline. Despite medication adjustments, her pain escalated, scoring a 9 on the Visual Analogue Scale (VAS). The underlying mechanisms of how SARS-CoV-2 impacts the nervous system remain unclear. Research suggests that the virus can invade the nervous system and trigger headaches by causing inflammation and vascular changes. Headache and loss of smell (anosmia) are thought to be linked to this direct neural invasion. Calcitonin gene-related peptide (CGRP) is key in migraine pathophysiology, involved in pain transmission and inflammation. Elevated levels of interleukin (IL)-6 and tumor necrosis factor alpha (TNF-a), common in COVID-19, also increase CGRP, influencing symptoms like cough, fever, and pain. Studies have found structural similarities between CGRP receptors and SARS-CoV-2 spike proteins, sug

Evolution of COVID-19 Reinfection and Immunity

In the early stages of the COVID-19 pandemic, reactivation and reinfection were considered rare. However, as the pandemic progressed, records for the length of infection and number of reinfections began to break. By October 2020, there were five cases of reinfection  with more severe second cases. By the end of 2021, prolonged positive tests were observed, such as a man in Bristol who remained SARS-CoV-2  positive for 290 days . A case report published in May 2023 (aren't academic reports obsolete by the time they are finally published?) asked " Is it possible to get Covid infection 3 times? " in the title. Now this question is rhetorical. In a recent  Malawi study , the risk of reinfection was highest in the immediate 3 to 6 months following the initial infection and declined substantially after that, and age demonstrated a significant association with reinfection. In  Southern Brazil , comparative genomic and phylogenetic analysis confirmed that the fourth reinfection w

Accelerated Aging after mRNA Vaccination

A recent study found significant destruction in ribosomal RNA structures after vaccination, a phenomenon that was enhanced by serial shots. This destruction led to massive inhibition of translation and transcription, affecting intra/inter neural signaling transfer and lipid metabolism. These processes are related to the aging process, and the destruction was identified even six months after vaccination. The cases described in cited papers include: 82-year-old female with colorectal cancer in remission: Complications of vaccination: abdominal pain, appetite loss, constipation, anemia, anorexia. Cancer relapsed after vaccination, leading to her death (patient 6 in Tanaka et al, 2022 : Archives of Clinical and Biomedical Research) 85-year-old female with esophageal cancer in remission: Complications of vaccination: dysphasia.  Cancer relapsed after vaccination, along with suspected microembolus in the brain, causing symptoms of memory loss, hoarseness, and dysphagia, leading to her death.