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Showing posts from February, 2022

Fatal outcomes in elderly patients after COVID-19 vaccination

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In the period 27 December 2020 to 15 February 2021, about 29 400 of Norway's nursing home patients (aged  61–103)  were vaccinated with the mRNA vaccine BNT162b2. During the same period, the Norwegian Medicines Agency received 100 reports of suspected fatal adverse reactions to the vaccine. An expert group has examined the 100 reported deaths and concluded that 10 (10 %) are most likely related to the vaccine while there could be a possible link for other 26 individuals (26 %).  A  recent review  of other 38  cases linking the COVID-19 vaccines and the death found the following causes of death: vaccine-induced immune thrombotic thrombocytopenia (VITT) (32), myocarditis (3), acute disseminated encephalomyelitis (ADEM) (1), myocardial infarction (1), and rhabdomyolysis (1) . More than half of these cases were in elderly individuals. Unfortunately,  there were only a few publications on postmortem diagnostics of adverse events linked to vaccination.  Here are 7 brief medical case

Acute liver failure after COVID-19 vaccination

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A 34-year-old health care worker with unremarkable past medical history,  no drug, alcohol and supplement usage, and no history of COVID-19,  received the first dose of  ChAdOx1nCov-19 vaccine.  Over the next couple of days after the vaccination, he reported headache, nausea, and dizziness as well as abdominal pain.  The abdominal pain was resisted to pantoprazole and  acetaminophen.  He was hospitalized on the fourth day after vaccination and transferred to liver transplantation center. At admission (fifth day after vaccination) his blood pressure was 110/70 mmHg, cardiac pulse rate was 110 beat per second, respiratory rate reached to 30 per minute and temperature was 37 °C with Spo2 94%. The physical exam revealed moderate to severe abdominal pain on palpitation  with the icteric sclera and petechial. The laboratory assessment at fifth day after vaccination demonstrated the increasing of AST, ALT, bilirubin,  D-dimer and elevated level of PT/INR.   His general status and blood values

46-year-old female dies from breakthrough COVID-19 less than 48 hours after positive test

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 A 46-year-old primary school teacher with no known comorbidities died less than 48 hours after testing positive for COVID-19, during the ebbing of Omicron wave in Australia. All staff on  NSW public school sites  are required to be  fully vaccinated against COVID- 19 and  are expected to access their booster shot when they become eligible. REFERENCES https://www.abc.net.au/news/2022-02-20/tributes-flow-for-michelle-hayes-covid-death/100846044 https://www.theaustralian.com.au/breaking-news/bowral-teacher-dies-less-than-48-hours-after-positive-covid-test/news-story/36fa0304497ed2fab8fc785f1f9780f7 https://www.nzherald.co.nz/world/covid-19-omicron-outbreak-nsw-teacher-dies-less-than-48-hours-after-positive-test https://www.dailymail.co.uk/news/article-10530181/Beloved-Bowral-school-teacher-dies-Covid-hours-testing-positive-Valentines-Day.html

Catecholamine-Mediated Stress Cardiomyopathy after COVID-19 Vaccination vs Infection

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A teenage boy of average weight with a history of attention deficit hyperactivity received his second dose of BNT162b2 mRNA vaccine and complained of a headache and gastric upset. He felt better by post-vaccine day 3 but was found dead in bed the following day. Autopsy cardiac findings included myocardial fibrosis and no evidence of SARS-CoV-2 infection. An overweight teenage boy with no prior health issues or SARS-COV-2 infection before his second dose of BNT162b2 vaccine did not have any complaints after receiving the vaccine. He was found dead in bed on the 4th day after the injection. Unique cardiac findings during autopsy included cardiac hypertrophy. The overall pattern of injury was consistent with “stress cardiomyopathy” with contraction bands and a neutrophilic/histiocytic infiltrate. There was global myocardial injury similar to that seen in the teenager discussed above, but with more widespread transmural ischemic changes and more interstitial inflammation, again with

Fatal breakthrough infections in solid organ transplant recipients

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In a cohort study of 664 722 patients who received at least 1 dose of a SARS-CoV-2 vaccine, solid organ transplant recipients had a higher rate for COVID-19 breakthrough infection and worse outcomes after full or partial vaccination, compared with persons without immune dysfunction.  We describe 4 fatal breakthroughs with liver and kidney transplant recipients aged 13-69.  Two vaccinated solid organ transplant recipients (68M, liver and 69M, renal transplant) infected with Alpha variant had severe pneumonia requiring intensive care admission and ventilatory support and subsequently died. Both got vaccinated with  BNT162b2 mRNA (Pfizer-BioNTech),  were on tacrolimus medication, spent over 40 days in ICU and received  Dexamethasone  and Tocilizumab as part of their COVID-19 treatment. Both had  Diabetes mellitus and  Hypertension. These cases were a part of case series of four fully vaccinated solid organ transplant recipients who developed SARS-CoV-2 variants of concern breakthrough in

Fatal Breakthrough COVID-19 in patients with kidney disorders

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In a sample from Brazilian SIVEP-Gripe database (Sistema de Informação de Vigilância Epidemiológica da Gripe), COVID-19 breakthrough infections associated with hospitalization and death were more frequent in older patients (age ≥60 years) and those with kidney disorders. Among 2777 patients with COVID-19 admitted to a hospital between January 5, 2021 and September 12, 2021, 257 were fully vaccinated ( 15 days or more after vaccine series completion ), and 112 of them died.  Vaccines have  limited impact on patients with kidney failure . As of 19th September 2021, 93% (n=5281) of p atients with kidney failure requiring kidney replacement therapy (KRT)   in Scotland had received two doses of an approved SARS-CoV-2 vaccine.  The Glasgow  study recorded 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness against infection and hospitalization was 33% (95% CI 0-52) and 38% (95% CI 0-57) respectively. 9.2% of fully vaccinated individuals died within 28 day

Canadian man diagnosed with Guillain-Barré Syndrome following 1st dose of ChAdOx1-S vaccine unable to get an exemption from 2nd dose

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A ~30-40-year-old male was given a dose of the AstraZeneca vaccine in April 2021. Within days, he started to have excruciating back pain. Then came the tingles on the side of his face — and then, paralysis. He was diagnosed with Guillain-Barré Syndrome (GBS), a rare condition that affects the nervous system. It can cause paralysis, muscle weakness, and even death.  This condition has been linked to COVID-19 vaccination with all types of vaccines and wide range of ages (eg,  Pfizer: 67-year-old male , Pfizer: 14-year old male ,   Astrazeneca: 66-year old  male) Review of 9 cases that occurred in persons with a mean age of 57.8 (range 20–86) years,  56.4% male, showed that most of the reported case-patients received ChAdOx1-S (25/39), followed by BNT162b2 (12/39) (Pfizer-BioNTech), Ad26.COV2.S (1/39) (Johnson & Johnson), and CoronaVac (1/39). The GBS rate after COVID-19 vaccination ranged from 1.8 to 53.2 cases/1 million doses. The Canadian man spent two months in the hospital, and t

Fatal COVID-19 soon after 2nd dose of Pfizer vaccine in an 88-year-old male

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An 88-year-old male patient was brought to the emergency department on July 25, 2021, with complaints of shortness of breath, headache, cough, and generalized body weakness. He was screened for SARS-CoV-2, and he tested negative on the rapid antigen test. A subsequent nasopharyngeal swab for the reverse transcription-polymerase chain reaction (RTPCR) test for SARS-CoV-2, however, yielded positive results. He presented with blood pressure (BP) of 136/62 millimeters of mercury (mmHg), a pulse of 113 per minute, oxygen saturation of 52% at room air, a body temperature of 37.3°C, and blood sugar at 6.2 mmol/lite. An examination of the respiratory system revealed coarse crackles with decreased air entry in both lung fields and all other systems were within normal limits. His medical history included diagnosis with benign prostatic hyperplasia (BPH) after a prostate biopsy in 2015. He received the first dose of the Pfizer-BioNTech vaccine on June 8, 2021, and the second dose on July 20, 2021

Study linking excess deaths and SARS-CoV2 vaccinations in Scotland

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  In Scotland, vaccination was found to be associated with an increase in excess deaths from mid/end January until end February for the oldest three age groups (45, 151 and 113 weekly excess deaths for 18/01, 25/01 and 01/02 respectively for the 80+ age group – which increased from -19 excess deaths on 11/01) There are more moderate but maintained excess deaths in 55-59, 60-64 and 65-69 between 25/01 and 15/02 (but it’s hard to say anything for 55-59 and 60-64 because less than 50% of those age groups has been vaccinated so far) There are no observable effects in the youngest age groups (but these have less than 12% vaccinated) This analysis doesn’t prove a causal link between vaccination and excess death. The main point is that in the age groups that have received the majority of vaccinations, the weekly number of excess deaths has been maintained (and increased in some age groups) throughout the first dose vaccination program, and

Vaccinated and Boosted 67-year old man with Down syndrome dies from COVID-19 during Omicron Wave

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A 67-year-old fully vaccinated and boosted man with Down syndrome (DS) died early February 2022 after he contracted COVID-19. The man spent 12 says in the hospital  and an intensive care unit due to his underlying health  conditions but was brought home and was cared by his family for the last 6 days preceding his death. The  man suffered a stroke 17 years ago.  Individuals with Down syndrome are presumed to be at high risk of severe CoVID-19, due to immune dysregulation and often compromised cardiopulmonary function. DS is caused by the presence of full or partial extra copy of chromosome 21 ( HSA21 ). REFERENCES The Austin American-Statesman, the major daily newspaper for Austin, the capital city of Texas: https://www.statesman.com/story/news/2021/12/21/donor-pays-off-loan-statesman-season-caring-austin-palliative-care-family/8962545002/ https://www.statesman.com/in-depth/news/2021/11/24/austins-judy-silva-brother-down-syndrome-season-for-caring/6254508001/ Also reported by the Inter

Deaths of elderly individuals wrongly given an extra dose of the vaccine

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A 103-year-old woman was erroneously given a fourth dose of the Covid-19 vaccine by a mobile vaccination team, soon after her 3rd shot.  The woman, a nursing home resident, was admitted to a hospital on Dec 16 - three days after receiving the extra dose.  She had pneumonia and low sodium levels and was subsequently diagnosed as having had a stroke. She died on Jan. 10th, 2022. ------------------ An 88-year-old male, survivor of COVID-19, was given 3rd dose of Moderna Covid Vaccine in error, shortly after the 2nd dose (1st dose was administered 2 months after his COVID-19 infection).  Next morning he was noted to act strange and was found unresponsive less than 2hrs after.  He was hospitalized and intubated. A few days later the family made the decision to remove him from the ventilator. He died on March 16, 2021 ------------------ A 93-year-old male fell ill on the day of his vaccination, 3rd dose of Pfizer vaccine. He  died 2 days later. Cause of death:  vaccine dosage error. -------

Vaccinated 71-year-old male dies from breakthrough COVID-19 on the 2nd day of symptom onset

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Of the 15 family members that gathered on Thanksgiving, 10 ended up getting COVID. Three of them — one vaccinated, another unvaccinated and the third one with unknown vaccination status — would die of the disease.  68-year-old double-vaccinated (but not boosted; ~8 months after her 2nd shot) female started feeling sick on the second day after the event. Next day she was treated at a local hospital and discharged shortly after. On the 6th day she broke her shoulder but did not remember how it happened. Other family members still felt fine at that time. On the 9th day she was admitted to the hospital. She would end up hospitalized at a hospital and a rehab facility for 17 days.  71-year-old double-vaccinated (but not boosted, ~8 months after his 2nd shot) overweight male started to feel unwell on the 7th day and died on the 9th day - while sitting in his easy chair shortly before an ambulance arrived to take his wife and son to the hospital. Unvaccinated 47-year-old overweight male was a