Medical Case Reports

The  human leukocyte antigen  ( HLA ) genes  encode proteins essential for mounting an immune response.  Immune systems of people with specific HLA types may be better or worse at mounting an immune response and generating antibodies to specific proteins.  HLA-A11  (A11) is one of serotypes with 10.8% frequency in worldwide population. It's most  common in East Asia. One of its variations,  HLA-A*11, has been linked with vaccine-induced  subacute thyroiditis (V-SAT) . This rare transient inflammatory thyroid disease is usually associated with pain and tenderness of the gland, as well as generalized somatic symptoms: from anxieties,  difficulty swallowing, changes in appetite,  malaise and fatigue to  complete prostration for weeks or months if left untreated. HLA-A*11:01:01:01 was found to be significantly associated with the severity of COVID-19.   SAT is the most common thyroid dysfunction following SARS-CoV-2 vacc...

A 90-year old woman weighting 40.5kg (89.3 pounds) develops anorexia after the first dose of the COVID-19 Pfizer vaccine (0.3 ml containing 30μg of mRNA). Vital records showed abrupt increases in the body temperature, systolic and diastolic blood pressure, and pulse, and decreases in the intake of meals and drinks and body weight. The patient lost 1/4 of her body weight by the time of death 28 weeks after the COVID-19 vaccination.  The patient also experienced hallucinations and decreased mental status, as well as decreased SpO 2  levels.  One month before death, her status was changed from level 2 (partial assistance) to level 5 (bedridden).  Before the injection her vitals were steady with exception of short-termed changes because of minor illnesses. Vital records restricted to the last 6 months (180 days;  Figure 2 ) show the pre-injection horizontal regression line, large + level change for temperature, pressures, and pulse, and – level change for meals and ...