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Pericardial effusion as a complication of vaccination against COVID-19

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We present two cases following inactivated virus and mRNA vaccines and discuss additional cases of fetal pericardial effusion after maternal COVID-19 vaccination.  A 34-year-old man without any significant past medical history experienced chills and fever 48 hours after inoculation of the Sinopharm vaccine. He had taken Acetaminophen to control the fever; however, on the third day post-vaccination, he developed an atypical pleuritic chest pain for which he was brought to our center. A pan-CT scan with intravenous contrast was performed and showed no findings suggestive of malignant lesions nor any lesions in favor of neoplastic processes. Peritracheal lymph nodes were found with less than 10 mm diameter showing benign reactive lymph nodes. The patient was on nonsteroidal anti-inflammatory drugs and Colchicine with suspicion for pericarditis but no improvement was seen in his condition evaluated by serial echocardiograms. Therefore, a pericardial window was inserted for him and the...