Fatal cerebral haemorrhage after COVID-19 vaccine

Previously healthy woman in her thirties develops headaches one week after vaccination with ChAdOx1 nCoV-19, is admitted in the emergency department with slurred speech, uncoordinated movements and reduced consciousness, dies from thrombocytopenia. Post mortem examination reveals antibodies to PF4 and fresh small thrombii the transverse sinus, frontal lobe and pulmonary artery.


Fatal cerebral haemorrhage
after COVID-19 vaccine

Comments

Post a Comment

Popular posts from this blog

Nimbus and Stratus: Cloudy With a Chance of Covid

Image
As we venture into the end of summer, there’s no denying that COVID-19 is making its move again. Covid waves always follow a seasonal pattern  - two waves per year: winter and summer or fall. So far, the smallest (not in terms of deadliness though, just the number of infected) wave hit during the winter of 2020-2021, while the Omicron surge of 2021-2022 took the crown for the biggest wave. Last year was a bit of a wild card, with the summer/fall wave being slightly taller than the winter one. However, so far, this year hasn’t had much of a summer/fall wave (yet) but hold on tight because things are looking a little more intense as we approach the winter. From December 2024 to February 2025, we experienced what could be called "Wave X," a quieter episode compared to earlier waves, but it still made its presence felt. Fast forward to August 2025, and we’re beginning to see the rise of the next wave—a little like what we saw in 2023 and 2024. According to Mike Hoerger’s post on ...
Read more

Boosting Immunity, Boosting Risk? The Surprising Link Between IgG4 and COVID Breakthrough Infections

Image
Post-Vaccination IgG4 and IgG2 Class Switching is linked to Increased Risk of SARS-CoV-2 Infections A new study published in Infectious Disease Practice has revealed a concerning correlation between the class switching of antibodies after COVID-19 mRNA booster vaccinations and a heightened risk of breakthrough infections. Specifically, the study found that elevated levels of IgG4 and IgG2 antibodies, which increase significantly following the third mRNA dose, are linked to an increased risk of symptomatic SARS-CoV-2 infections.  The study analyzed a longitudinal subset of 83 healthcare workers who received three doses of the COVID-19 vaccine. Additionally, they included 66 healthcare workers from the same cohorts who were analyzed at a specific timepoint (T9) corresponding to May 2022, four months after the first booster vaccination. The study, conducted by a team of researchers from Spain, tracked the immune responses of healthcare workers over nearly three years. They observed ...
Read more

Wave X

Image
From wild type to Alpha (B.1.1.7), Delta (B.1.617.2), Omicron BA.1, BA.2, BA.5,  BQ.1/BA.2.75,  XBB, JN.1, FLiRT variants and now XEC and LP.8.1 (BA.2.86.1), the virus keeps evolving, continuously demonstrating its ability to adapt and mutate.  As we enter the tenth wave of COVID-19 in the U.S, the XEC variant has emerged as the dominant strain - in line with expectations. It could be " a weak leading variant "  but will it be a " very muted holiday wave relative to all prior years , due to weak evolution and large summer numbers"?  Until recently in the US KP.3.1.1 was dominating wastewater samples and accounting for a considerable proportion of infections. Looking at the growth advantages of variants over the last year led to predictions of significantly lower impact  than JN.1 that "XEC should only modestly bump what the winter wave would be without any new variant" by one of COVID forecasters . But other variants are also gaining traction. The off...
Read more