Fatal cerebral haemorrhage after COVID-19 vaccine

Previously healthy woman in her thirties develops headaches one week after vaccination with ChAdOx1 nCoV-19, is admitted in the emergency department with slurred speech, uncoordinated movements and reduced consciousness, dies from thrombocytopenia. Post mortem examination reveals antibodies to PF4 and fresh small thrombii the transverse sinus, frontal lobe and pulmonary artery.


Fatal cerebral haemorrhage
after COVID-19 vaccine

Comments

Post a Comment

Popular posts from this blog

Nimbus and Stratus: Cloudy With a Chance of Covid

Image
As we venture into the end of summer, there’s no denying that COVID-19 is making its move again. Covid waves always follow a seasonal pattern  - two waves per year: winter and summer or fall. So far, the smallest (not in terms of deadliness though, just the number of infected) wave hit during the winter of 2020-2021, while the Omicron surge of 2021-2022 took the crown for the biggest wave. Last year was a bit of a wild card, with the summer/fall wave being slightly taller than the winter one. However, so far, this year hasn’t had much of a summer/fall wave (yet) but hold on tight because things are looking a little more intense as we approach the winter. From December 2024 to February 2025, we experienced what could be called "Wave X," a quieter episode compared to earlier waves, but it still made its presence felt. Fast forward to August 2025, and we’re beginning to see the rise of the next wave—a little like what we saw in 2023 and 2024. According to Mike Hoerger’s post on ...
Read more

Toothache as a side effect of vaccination

Image
Previously we presented case reports with oral side effects of COVID-19 vaccine due to mucocutaneous reactions. Trigeminal neuralgia (TN) could be another reason for oral manifestations, including severe tooth pain.  A 45-year-old female was admitted to a research hospital with 3 days of facial and jaw pain, fatigue and toothache following the first dose of Pfizer-BioNtech vaccine against SARS-CoV-2. The features of the pain were unilateral, acute onset, and severe, on the lower right side of the face. It was triggering with brushing her teeth and putting on makeup. The case was considered as trigeminal neuralgia. Pregabalin failed to control the pain, while amoxicillin/clavulanic acid (despite normal X-rays) led to angioedema and worsening of her general condition. However, with steroid treatment, the patient eventually recovered.  A 36-year-old woman was admitted to the Emergency Ward due to chronic pain attacks in the left side of her face. The pain appeared tw...
Read more

The IgG4 Puzzle: Why Boosters May Weaken One Defense but Strengthen Another

Image
Post-Vaccination IgG4 and IgG2 Class Switching is linked to Increased Risk of SARS-CoV-2 Infections A new study published in Infectious Disease Practice has revealed a concerning correlation between the class switching of antibodies after COVID-19 mRNA booster vaccinations and a heightened risk of breakthrough infections. Specifically, the study found that elevated levels of IgG4 and IgG2 antibodies, which increase significantly following the third mRNA dose, are linked to an increased risk of symptomatic SARS-CoV-2 infections.  The study followed a longitudinal cohort of 83 healthcare workers who received three vaccine doses, with an additional 66 participants analyzed at a specific timepoint (T9, May 2022), four months after the first booster. Conducted in Spain, the research tracked immune responses over nearly three years, revealing that the proportion of non-cytophilic antibodies (IgG4 and IgG2) increased relative to cytophilic subclasses (IgG1 and IgG3) after the booster. Th...
Read more