Fatal COVID-19 Breakthrough Case Following Severe Reaction to ChAdOx1 nCoV-19 Vaccine

MANUSCRIPT SUBMITTED FOR PEER REVIEW   

SUMMARY  

We report a case from an ongoing COVID-19 vaccines long-term safety study led by one of the authors. We describe a fatal SARS-CoV-2 breakthrough infection occurring after a serious adverse reaction to ChAdOx1 nCov-19 vaccine.

Two years into the outbreak, COVID-19 treatment and preventive care are still not sufficiently personalized. Radiographic and laboratory findings commonly used to monitor progression to severe disease fail to select appropriate treatment or subsequent immunization regimen while predicting response to therapy remains a clinical challenge.

Retrospectively analyzing post-immunization adverse events helps in understanding the relationship between host susceptibility and vaccine efficacy, which may ultimately lead to improved interventions.



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