Fatal MIS-A after vaccination soon after natural infection

 

Previously healthy young adult experienced mild case of COVID-19 and got vaccinated on the 6th day of symptom onset. 20 days later he receives his second dose of the vaccine that causes fatigue and malaise resolved within 2 days. 22 days later he has onset of new fever, malaise, headache, and odynophagia, develops tachycardia, thrombocytopenia and eventually dies from severe multisystem organ failure despite treatment.  

Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

Abstract

We describe a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination. The immunopathology of this syndrome, regardless of vaccination status, remains poorly understood.


Grome HN, Threlkeld M, Threlkeld S, Newman C, Martines RB, Reagan-Steiner S, Whitt MA, Gomes-Solecki M, Nair N, Fill MM, Jones TF. Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination. Emerging infectious diseases. 2021 Nov;27(11):2914.

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See also

Multisystem Inflammatory Syndrome in Adults after SARS-CoV-2 infection and COVID-19 vaccination - PubMed (nih.gov)

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