Negative effect of the second dose of the BNT162b2 vaccine in a significant percentage of individuals with previous COVID infection

The response to the first and second doses of BNT162b2 vaccine was evaluated in 197 health care workers from Hospital Clinico San Carlos, 98 of whom had a previous COVID-19 infection. Antibody titers were measured using the SARS-CoV-2 IgG II Quant assay (Abbott Diagnostics). 

After the second dose vaccine administration, a large increase in antibody levels were observed in all those without previous infection, but responses in the previously infected cohort were different. While 55% achieved higher titers, there was no significant difference in 6% and ~39% had a statistically significant drop in IgG anti-RBD antibodies after the administration of the second dose of BNT162b2.


Highlights

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Responses to immunization with Pfizer – BioNTech vaccine in health care workers.

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Immune response in partially vaccinated is as high as with fully vaccinated in those with no previous COVID infection (NI)

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38.8 % of those with no previous COVID infection (NI) showed a decrease in antibody titer with the second dose of BNT162b2

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Baos E, Delgado-Iribarren A, Bardón I, Alvaréz M, Rodríguez-Avial I, Culebras E. Negative effect of the second dose of the BNT162b2 vaccine in a significant percentage of individuals with previous COVID infection. International Journal of Infectious Diseases. 2022 Jan 1;114:85-7.

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