Risk Factors for Severe COVID-19 Outcomes Among Vaccinated Individuals

Why do people die from COVID-19 despite vaccination?  There is no comprehensive explanation for this yet. A new Morbidity and Mortality Weekly Report (MMWR) emphasizes the usual risk factors: 36 people that died from fatal breakthroughs were either age 65 or older or had at least one of these conditions: diabetes mellitus, immunosuppression, chronic kidney disease, chronic liver disease, chronic neurologic disease, chronic cardiac disease, or chronic pulmonary disease. Fatal breakthrough cases under 65 and even under 18 have been previously reported but no details were given yet. 

Among 1,228,664 persons who completed primary vaccination during December 2020–October 2021, severe COVID-19–associated outcomes (189, 0.015%) or death (36, 0.0033%) were rare. Risk factors for severe outcomes included age ≥65 years, immunosuppressed, and six other underlying conditions. All persons with severe outcomes had at least one risk factor; 78% of persons who died had at least four.



Title: 

Risk Factors for Severe COVID-19 Outcomes Among Persons Aged ≥18 Years Who Completed a Primary COVID-19 Vaccination Series — 465 Health Care Facilities, United States, December 2020–October 2021

Authors:
Christina Yek, MD1,2,*; Sarah Warner, MPH1,*; Jennifer L. Wiltz, MD3; Junfeng Sun, PhD1; Stacey Adjei, MPH3; Alex Mancera, MS1; Benjamin J. Silk, PhD3; Adi V. Gundlapalli, MD, PhD3; Aaron M. Harris, MD3; Tegan K. Boehmer, PhD3; Sameer S. Kadri, MD
1Clinical Epidemiology Section, Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland; 2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland; 3CDC COVID-19 Response Team.


READ MORE

Yek C, Warner S, Wiltz JL, et al. Risk Factors for Severe COVID-19 Outcomes Among Persons Aged ≥18 Years Who Completed a Primary COVID-19 Vaccination Series — 465 Health Care Facilities, United States, December 2020–October 2021. MMWR Morb Mortal Wkly Rep 2022;71:19–25. DOI: http://dx.doi.org/10.15585/mmwr.mm7101a4

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