Young COVID-19 vaccine breakthrough fatalities
The clinical course of COVID-19 depends on the complex interaction between genetic and environmental factors which might result in immune hyperactivation or dysregulation. Risk factors for severe outcomes include cardiovascular and renal diseases, hypertension and diabetes, old age and host genetics.Several genome-wide association studies identified candidate genes and non-coding regions associated with the severity of COVID-19 and post-COVID sequelae. Vaccine effectiveness may fail for individuals with particular genetics and we need more studies and more medical case reports to develop personalized preventative and curative approaches. Until then we can read the news.