Adverse Ocular Events After SARS-CoV-2 vaccines
SARS‑CoV‑2 virus provokes an insult to every singleretinal structure, including retinal pigment epithelium (RPE) and photoreceptors, leading to a progressive impairment.
Multiple cases of ocular inflammation after COVID-19 vaccines have been also reported.
A 19-year-old male was diagnosed with Keratitis 2 days after 2nd dose of inactivated COVID-19 vaccine. He was treated with topical application of ganciclovir ophthalmic gel and ciclosporin and intravenous injection of ganciclovir.Another 19-year-old male without a history of eye disease experienced blurry vision three weeks after the second dose of inactivated COVID-19 vaccine (CoronaVac, Sinovac Life Sciences, Beijing, China). He was diagnosed with viral keratitis and received ganciclovir ophthalmic gel and levofloxacin eye drops without relief of the ocular symptoms. After admission and examination in another hospital, the patient was found to have poor eyesight (best-corrected visual acuity of 20/60 in the right eye and 20/100 in the left eye). Slit-lamp examination revealed conjunctival hyperemia, rough corneal epithelium, irregular patchy infiltration of the entire cornea, and positive corneal fluorescence staining
The four patients from a study published on June 29 exhibited ocular inflammatory reactions on the same day after receiving an inactivated SARS-CoV-2 vaccine, with the medical diagnosis of Vogt-Koyanagi-Harada, Ponser-Schlossman, secondary post-inflammatory glaucoma, and iridocyclitis, respectively. The ocular inflammatory reactions of these four patients were resolved with the administration of oral or topical corticosteroids.
Ren J, Zhang T, Li X, Liu G. Ocular Inflammatory Reactions following an Inactivated SARS-CoV-2 Vaccine: A Four Case Series. Ocular Immunology and Inflammation. 2022 Jun 29:1-6.
Neri P, Pichi F. SARS-CoV-2 and the eye: the pandora's box of ocular immunology. Journal of Ocular Pharmacology and Therapeutics. 2021 Nov 1;37(9):502-9.
Pang K, Pan L, Guo H, Wu X. Case report: associated ocular adverse reactions with inactivated COVID-19 vaccine in China. Frontiers in medicine. 2022:2928.