Rapid Progression of Prediabetes to Diabetes after Booster Dose
Complete blood count (CBC) was normal; blood glucose was severely elevated with mild corrected hyponatremia; elevated anion gap metabolic acidosis with glucosuria and ketonuria. He received an insulin drip, normal saline, and potassium in the intensive care unit.
On a three-week endocrinology follow-up, his repeat HbA1c improved to 10.3%. He continues to be insulin dependent and regularly follows up with his physician.
Another report describes 64-year-old female with hypertension (HTN) and pre-diabetes mellitus (DM) (for 20 years) who developed new-onset Latent Autoimmune Diabetes in Adults (LADA) (presenting with diabetic ketoacidosis) one week after 2nd dose of Pfizer-BioNTech COVID-19 vaccine.
A recent study from the Smidt Heart Institute at Cedars-Sinai Medical Center found that the combined risk of Type 2 diabetes after COVID-19 exposure—accounting for both vaccinated and unvaccinated patients—was 2.1%, with 70% occurring after COVID-19 infection versus 30% happening prior to COVID-19 exposure. The risk of Type 2 diabetes after COVID-19 exposure for unvaccinated patients was 2.7%, with 74% occurring after COVID-19 infection versus 26% happening prior to COVID-19 exposure. The risk of Type 2 diabetes after COVID-19 exposure for vaccinated patients was 1.0%, with 51% occurring after COVID-19 infection versus 49% happening prior to COVID-19 exposure.
Kshetree B, Lee J, Acharya S. COVID-19 Vaccine-Induced Rapid Progression of Prediabetes to Ketosis-Prone Diabetes Mellitus in an Elderly Male. Cureus. 2022 Sep 6;14(9):e28830. doi: 10.7759/cureus.28830. PMID: 36225440; PMCID: PMC9535996.
Bally K, Ji B, Soni L. COVID-19 Vaccine-Induced Latent Autoimmune Diabetes in Adults. Cureus. 2023 Jan 14;15(1):e33762. doi: 10.7759/cureus.33762. PMID: 36793809; PMCID: PMC9924027.
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