Sudden onset of vitiligo after COVID‐19 vaccine

A 33‐year‐old healthy female presented with a 45‐days history of milky‐white well‐demarcated, oval and liner‐shaped macules on her trunk, neck and back which had appeared 1 week after receiving her first dose of Pfizer‐BioNTech COVID‐19 vaccine. The second dose of vaccine was injected 1 months later without the appearance of new macules. She had family history of vitiligo (father) but never suffered from it before. Similar case was observed for a 13-year old girl with family history (father and paternal uncle).  



Similar cases were reported 1 week after the first dose of Pfizer–BioNTech COVID‐19 vaccine in a 58‐year‐old man without family history for vitiligo suffering from ulcerative colitis 3. 
A 69-year-old woman without personal/familiar history of vitiligo and other autoimmune diseases developed vitiligo several days after her first dose of Moderna (mRNA‐1273) COVID‐19 vaccine.  The macules progressed in size, number and degree of hypopigmentation after the booster dose.
A 47-year old male with a history of ankylosing spondylitis for nearly 40 years experienced new onset vitiligo 1 week after the first dose of Pfizer‐BioNTech vaccine BNT162b2 (Comirnaty®). Many more cases have been reported including a 69-year-old male and 35-year old woman.

REFERENCES

Ciccarese G, Drago F, Boldrin S, Pattaro M, Parodi A. Sudden onset of vitiligo after COVID-19 vaccine. Dermatol Ther. 2022 Jan;35(1):e15196. doi: 10.1111/dth.15196. Epub 2021 Nov 15. PMID: 34751491 PMCID: PMC8646249 doi: 10.1111/dth.15196

Aktas H, Ertuğrul G. Vitiligo in a COVID‐19‐vaccinated patient with ulcerative colitis: coincidence? Clin Exp Dermatol. 2021. doi: 10.1111/ced.14842 [PMC free article] [PubMed] [CrossRef[]

Kaminetsky J, Rudikoff D. New‐onset vitiligo following mRNA‐1273 (Moderna) COVID‐19 vaccinationClin Case Rep. 2021;9:e04865. doi: 10.1002/ccr3.4865 [PMC free article] [PubMed] [CrossRef[]

Bukhari AE. New‐onset of vitiligo in a child following COVID‐19 vaccinationJAAD Case Rep. 2022;22:68–9. [PMC free article] [PubMed[]

Nicolaidou E, Vavouli C, Koumprentziotis IA, Gerochristou M, Stratigos A. New-onset vitiligo after COVID-19 mRNA vaccination: A causal association? J Eur Acad Dermatol Venereol. 2022 Aug 16:10.1111/jdv.18513. doi: 10.1111/jdv.18513. Epub ahead of print. PMID: 35971993; PMCID: PMC9538607.

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