Besides vaccine-induced myocarditis, there could be other cardiovascular complications, such as post-vaccinal Kounis syndrome (also referred to as allergic angina) or Vasospastic Angina (VSA). The latter form of angina pectoris is characterized by severe pain in the chest (caused by coronary artery spasm, which consists of a sudden occlusive vasoconstriction of a segment of an epicardial artery, resulting in a dramatic reduction of coronary blood flow). It can occur at rest, with transient electrocardiogram modifications and preserved exercise capacity. COVID-19 vaccination may increase coronary artery spasticity.41-year-old male patient was referred for chest pain at rest following mRNA vaccination; he had never experienced chest pain prior to vaccination. He was diagnosed by an acetylcholine (Ach) provocation test that showed multivessel vasospasm. After the initiation of treatment with a calcium channel blocker and nitrate, no further exacerbation of chest pain was observed.